BECN1 and neoplasm: Indeed, in our study, by taking the intensity of normal colonic staining as a marker for tumour reactivity, we managed to identify four distinct patterns of Beclin 1 expression: underexpression of Beclin 1, which was evident in 15.5% of tumours, the normal-like pattern, which was present in 40.6%, and overexpression of Beclin 1, which was detected in the remaining 43.9% of cases.