ERBB2 and neoplasm: VN/124-1 tumours demonstrated increase in growth factor signalling with an increase in expression of IGFR1 (6.9-fold), p-HER2 (1.9-fold), p-MAPK (3-fold), p-mTOR (1.6-fold), p-P70S6K (2.6-fold), and p-PS6 (1.2-fold) (Figure 4B).