MTOR and neoplasm: In this report, we have investigated whether tumour growth of apparent castrate-resistant tumours could be effectively inhibited by combining an mTOR inhibitor (everolimus, RAD-001, a rapamycin analogue inhibitor that blocks the downstream signalling cascade in vitro and in vivo (Boulay et al, 2004; Vignot et al, 2005)) with our novel compound VN/124-1.