Xiao et al (2003) demonstrated an inhibitory as well as an activating effect on hTERT transcription mediated through different ETS-binding sites. In this study, increased ETS1 and reduced hTERT expression by WT1 may suggest a negative role of ETS1 in hTERT transcriptional regulation in ccRCC. This evidence concerns the gene WT1 and nonpapillary renal cell carcinoma.