To further address the functional consequences of a possible link between ErbB2 and IGFBP3 regulation and a possible role in breast cancer, cell-based assays were performed in the ErbB2-overexpressing and invasive breast cancer cell line SKBR3 after knocking down ErbB2 and IGFBP3 expression. The gene discussed is IGFBP3; the disease is breast carcinoma.