Since ADAMTS1 and FP receptor [7] are both expressed within the glandular and vascular compartments in endometrial adenocarcinoma, we investigated the potential regulation of ADAMTS1 in endometrial adenocarcinoma cells by PGF2α via the FP receptor using endometrial adenocarcinoma cells stably expressing the FP receptor to the levels observed in endometrial cancer (Ishikawa FPS cells; [10]). This evidence concerns the gene ADAMTS1 and endometrial cancer.