Our laboratory and others have demonstrated elevated expression of prostaglandin-endoperoxide synthase (PTGS, also called cyclooxygenase or COX)-2, biosynthesis of prostanoids [5,6], and elevated expression of prostanoid receptors [7], such as the F-prostanoid (FP or PTGFR) receptor in endometrial adenocarcinomas [7]. Here, PTGS2 is linked to endometrium adenocarcinoma.