Moreover, we have shown that elevated PGF2α-FP receptor signalling in endometrial adenocarcinoma leads to upregulation of tumorigenic genes such as PTGS2 [8] and angiogenic genes such as FGF2 [9] and VEGF [10] which regulate vascular function in a paracrine manner [11]. The gene discussed is PTGS2; the disease is endometrium adenocarcinoma.