Since the antibody concentration in our study was optimised for staining in the cancer tissues, we believe that the minimal immunostaining observed in the proliferative phase endometrium reflects the lower amount of ADAMTS1 protein in the normal endometrium compared with endometrial cancer and confirms our observations of differential mRNA expression in cancer and normal endometrial tissue presented in figure 1. This evidence concerns the gene ADAMTS1 and endometrial cancer.