RYR2 and ventricular tachycardia: The incidence of adverse events, including syncope, ventricular tachycardia and ventricular fibrillation at 40 years of age is about 80%,2 and between 20 and 30 years, the incidence of sudden cardiac death is 30 to 50%.3 Currently, there are two known genetic mutations in CPVT, namely, RyR2 and CASQ2.4 These two ion channels mediate the transportation of calcium ions from the sarcoplasmic reticulum into the cytoplasm.