Estimated protective efficacy against malaria for 35 days post 3 and 9 month dose (posterior median and 95% credible interval) and up to 12 months of age of SP IPTi when the parasite population has no resistance mutations, all carry the dhfr triple mutation, all carry the dhps double mutation or all carry the quintuple mutation (both the dhfr triple and dhps double mutations). The gene discussed is DHPS; the disease is malaria.