PML and viral infectious disease: Proteins that efficiently disrupt PML-NBs (HCMV IE1 and EBV Zta) are expressed within infected cells in vitro prior to the time when the CHPKs are expressed [101], [102], so the ability of the HHV-4 and HHV-5 CHPKs to decrease the numbers of PML-NBs when ectopically expressed may have limited relevance during viral infection.