The most significant association (rs7890572, P = 3.8×10−10) was observed with a linear triglyceride trajectory effect (i.e., SNPxAGE effect) on the X chromosome within the IL1RAPL1 gene and near the gene encoding glycerol kinase (GK), in which mutations have been implicated in pseudo-hypertriglyceridemia, caused by high levels of glycerol creating measurement artifacts in the triglyceride assay [14]. The gene discussed is GK; the disease is hypertriglyceridemia.