The overall lack of association between Gly460Trp ADD1 gene polymorphism and hypertension and the discrepancy of results between Caucasians, Asians and blacks might be because of other unidentified polymorphisms that exist in the ADD1 gene that affect the susceptibility to hypertension or other loci that might be in linkage disequilibrium with the examined polymorphism of ADD1 gene. The gene discussed is ADD1; the disease is hypertensive disorder.