ADD1 and essential hypertension: The common molecular variant of the ADD1 gene causing the substitution of tryptophan instead of glycine (Gly460Trp) at amino acid position 460 was found to be associated with increased risk of hypertension[9] and other cardiovascular risk factors such as hyperlipidemia[10] and left ventricular hypertrophy.[11] There are studies reporting the association between the ADD1 gene polymorphism and susceptibility to essential hypertension but the results have been inconsistent and inconclusive.