KDR and Miyoshi myopathy: The pre-treatment of either 5 μM or 10 μM lovastatin for 24 hrs prior to the addition of 0–25 μM concentrations of the VEGFR-TKIs for 48 hrs resulted in co-operative cytotoxicity in both MM cell lines and HUVEC treated with either VEGFR-TKI (Figure 6A).