SHD and glioblastoma: Among these genes, of particular interest, were the Hedgehog pathway transcription factor GLIS3 (amplified at 9p23 and increased in PN-GBM), Meningioma 1 (MN1), RAS-like 10A (RASL10A), Src homology 2 containing transforming protein D (SHD), and Dishevelled associated activator of morphogenesis 2 (DAAM2), all amplified in PN-OA samples and increased in PN-OA relative to PN-GBM.