For example, MCM7 (minichromosome maintenance protein 7) is the host gene for three of the miRNAs (miR-25, miR-93 and miR-106b) we identified and has been reported to be amplified or over-expressed in human malignancies including prostatic, pancreatic, thyroid, cervical and colorectal cancers [49], [50], [51], [52], [53], [54]. This evidence concerns the gene MCM7 and colorectal cancer.