On univariate analysis, age, diabetes duration, hypercholesterolemia, hypertension, mycroalbuminuria, retinopathty, PAD, CAD, previous TIA/Stroke, Il-6 plasma levels, resistin plasma levels were significantly associated with diabetic foot presence, whereas adiponectin plasma levels were negatively associated with diabetic foot (see table 4). This evidence concerns the gene RETN and familial hypercholesterolemia.