On univariate analysis, age, diabetes duration, hypercholesterolemia, hypertension, mycroalbuminuria, retinopathty, PAD, CAD, previous TIA/Stroke, Il-6 plasma levels, resistin plasma levels were significantly associated with diabetic foot presence, whereas adiponectin plasma levels were negatively associated with diabetic foot (see table 4). The gene discussed is IL6; the disease is familial hypercholesterolemia.