There was a significant negative correlation between adiponectin and diabetes duration (r = -0.37; p < 0.05); hypertension (r = -0.32; p < 0.05), dyslipidaemia (r = 0.39; p < 0.0001), retinopathy r = -0.28; p = 0.40); PAD (r = 0.20; p = 0.021), previous TIA/Stroke (r = -0.30; p = 0.021), neuropathy (r = -0.31; p > 0.0001), diabetic foot grade (r = -0.29; p < 0.05)(see table 3). This evidence concerns the gene ADIPOQ and neuropathy.