Jeffcoate et al [10] al, suggested that an inflammatory cascade through increased expression of proinflammatory cytokines, including TNF-α and interleukin-1β exist in diabetic foot, whereas no study, to our knowledge, evaluated the role of adiponectin, resistin and immune-inflammatory biomarkers such as inflammatory cytokines in patients with diabetic foot in comparison with diabetic subjects without foot complications. This evidence concerns the gene RETN and diabetic foot.