Nevertheless owing to the fact that the mechanisms that control expression of different cytokines are often related and TNF-α stimulates expression of IL-1 and IL-6, and IL-1 can induce both IL-6 and TNF-α, to evaluate only IL-6 expression in our patients with diabetic foot could be a sufficient proof of immuno-inflammatory activation in diabetic patients with foot complications. The gene discussed is IL6; the disease is complication.