Moreover, P450 GDEPT may be useful in treating a broad spectrum of cancers, including breast cancer, melanoma, pancreatic cancer, and metastatic liver cancer [14-17]; 3) mammalian P450 subfamily 2B enzymes, in particular rat CYP2B1 [18], human CYP2B6 [10,11], and dog CYP2B11 [19,20], are effective catalysts of CPA activation. The gene discussed is CYP2B6; the disease is melanoma.