APP and Dravet syndrome: Particularly, crucial genes involved in the immune response, such as interferon receptors (IFNAR1 and IFNAR2), and oxidative stress, such as SOD1, S100B and APP - recently implicated in DS neurotoxicity from elevated expression of free radicals [39] - were highly up-regulated in DS vs euploid EPCs (Figure 3B; Additional file 4: Supplemental Table S2).