We had from 73% to 99% chance to detect a dominant effect of the three studied polymorphisms in PXR using the ORs from the study of Dring [61] of 1.3-2.9 and similarly more than 84% chance of detecting a dominant effect with an OR of 1.5 in LXR. Our findings do therefore not support important roles of PXR and LXR in CRC etiology. The gene discussed is NR1I2; the disease is colorectal carcinoma.