We investigated the association between polymorphisms in NFkB (NFkB1) -94 insertion/deletion ATTG (rs28362491), PXR (NR1I2) A-rs1523127-C, C-rs2276707-T, A-rs6785049-G, LXR (NR1H2) C-rs1405655-T, T-rs2695121-C and risk of CRC, as well as interactions between genes and consumption of red and processed meat, smoking status and use of NSAID in relation to the development of CRC, in a case-cohort study nested in the prospective population-based Danish Diet, Cancer and Health study. Here, NR1I2 is linked to cancer.