In conclusion, we have used a comprehensive approach for the delineation of the individual maternal, paternal, and fetal genotypes for the risk of preeclampsia, utilizing for the first time the combined analysis of three key gene polymorphisms, affecting the activity of biotransformation enzymes (GSTP1 and eNOS) in detoxifying processes and/ or the endothelial function of placenta (LPL) in a different ethnic population never analyzed before by this approach. Here, NOS3 is linked to preeclampsia.