The importance of adenosine among other mediators of CIN, such as OFRs, prostaglandins, and angiotensin converting enzymes is further emphasized by the finding that the inhibition of adenosine re-uptake by dipyridamole significantly increases renal impairment by contrast media and leads to a 70% depression of total renal perfusion. Here, ACE is linked to cervical squamous intraepithelial neoplasia.