EGFR and non-small cell lung carcinoma: The small molecule tyrosine kinase inhibitor (TKI), gefitinib (Iressa; AstraZeneca, Wilmington, DE), targets the epidermal growth factor receptor (EGFR) was tested in chemotherapy-refractory NSCLC patients, on the basis of their frequent expression of EGFR and their poor response to standard therapies.