Some studies listed a number of proteins that were nitrated in cancer including lung cancer.[37, 45, 46, 54] It is known that nitration of some of these proteins, e.g., aldolase and manganese superoxide dismutase (MnSOD), causes loss of their activities.[55] Determination of these target proteins may allow other researchers in the cancer field to evaluate them as potential disease markers and to determine novel pathways that may be involved in carcinogenesis. This evidence concerns the gene SOD2 and lung cancer.