FOS and infection: The reduced levels of c-Fos activation at 3 hr with the two hyperfilamentous mutants can be explained partly by their reduced level of adherence (Figure S3) and partly by the lack of fungal-epithelial cell contact (i.e., the wild-type yeast cells settled rapidly onto the epithelial surface prior to hypha formation, whereas the hyperfilamentous strains “floated” for a prolonged time period before gradually settling, thus reducing the multiplicity of infection [MOI] and threshold level of activation).