Examination of ovarian tumor extracts and cell lines by Western blot revealed increased expression of LRG1 protein in malignant serous tumors and ovarian cancer cell lines compared to their respective controls, as well as the presence of several isoforms of LRG1, though notably the ~47 kD LRG1 band was most intense in each of the malignant ovarian tumor protein extracts. This evidence concerns the gene LRG1 and ovarian neoplasm.