Supporting the premise that BoHV-5 entry into the CNS is facilitated by leukocytes, like for other herpesviruses, we also suspect that virus infections activate the AOP-1, MMP-9 and SNAP-25 proteins in the inflammatory infiltrates, which has been described recently as being composed by CD3 + T lymphocytes [17]. Here, PRDX3 is linked to viral infectious disease.