By contrast, the serum S. aureus EV-specific IgE levels were significantly higher in both 6–9 year aged and >9 year aged AD patients than in age-matched healthy subjects; this IgE levels were elevated in 33.3% of 6–9 years aged and 40% of >9 years aged AD patients (Fig. 6B). The gene discussed is IGHE; the disease is Alzheimer disease.