Cygb mRNA was detected in all aerobic GBM cell lines (controls), and when cultured under hypoxic conditions (0.6% O2 × 48 h), all cell lines showed significantly increased expression of Cygb mRNA (M006x, M010b and U87T, p < 0.05; M006xLo and M059J, p < 0.001) (Figure 1). The gene discussed is CYGB; the disease is glioblastoma.