RHOC and neoplasm: Despite the high homology of RhoA and RhoC, RhoA has been shown to regulate the activities of multiple transcription factors, most of which are implicated in the cancer progression [21] by modulating cancer cell adhesion, contraction, movement, release of cellular adhesion, degradation of extra-cellular matrix, and invasion into blood or lymph vessels [22,23], while RhoC contributes to tumor development, especially to invasion and metastasis of cancer cells [24,25].