The higher (5 μM) dose of M344 in a panel of human derived cancer cell lines, MCF-7 (breast adenocarcinoma), PC3 (prostate carcinoma), SK-OV3 (ovarian carcinoma), and A549 (lung carcinoma) demonstrated consistent up-regulation of ATF3 protein expression (Figure 1A). This evidence concerns the gene ATF3 and prostate carcinoma.