Thus, we have demonstrated that 17-AAG-dependent inhibition of NF-κB activity is tightly associated with transcriptional repression of Survivin and cIAP1 anti-apoptotic genes, thus decisively contributing to the cytotoxic potency of 17-AAG by decreasing the required "apoptotic threshold" in bladder cancer cells [38]. Here, BIRC5 is linked to urinary bladder carcinoma.