These results conspicuously differ from some of those obtained in Brattleboro rats (Mlynarik et al. 2007) or with Avpr1b antagonist administration, mainly in rats (see below), and strongly suggest that the Avpr1b KO mouse is not an appropriate model for examining stress-induced anxiety or depression (e.g. see Kalueff et al. 2007). The gene discussed is AVPR1B; the disease is major depressive disorder.