S100B and psychotic disorder: However, whereas in early studies the increased levels of S100B in patients with schizophrenia have been reported to occur without an indication for significant glial or neuronal damage, a finding that has been interpreted as an indirect evidence for increased active secretion of S100B by astrocytes during acute psychosis [97], other studies have shown that astrocyte and/or oligodendrocyte activation occurs in schizophrenic patients [98, 99].