S100B and ischemia: Experimental evidence suggests that administration of arundic acid (ONO-2506), an agent suggested to inhibit S100B synthesis [37], in a rodent ischemia model results in inhibition of overexpression of S100B in astrocytes and the subsequent activation of signaling pathways in the peri-infarct area, in a reduction of delayed infarct expansion and in amelioration of neurologic deficits [38].