So it would be interesting to investigate the possibility of regulatory mutations in various iron disorders, in particular when type 4 hemochromatosis is present in the absence of coding region mutations or in all cases of familial hyperferritinemia and in sporadic cases in the absence of known secondary causes (i.e., inflammation, malignancy infection or dysmetabolism) where “ferroportin disease” should be suspected. Here, SLC40A1 is linked to hemochromatosis type 4.