INSR and metabolic dysfunction-associated steatotic liver disease: In addition, single nucleotide polymorphisms (SNPs) in genes involved in inflammation, oxidative stress, and fibrogenesis have been associated with the severity of NAFLD [14-19], and recently it has been demonstrated that SNPs influencing Insulin receptor activity predispose to liver damage in NAFLD, confirming that insulin resistance has a causative role in the progression of liver disease [20].