Since it is possible that these SNPs may confer a small increase in the risk of NASH progression, which could not be detected by the sample size of this study (this is especially true for the PPARγ2 SNP, due to the lower prevalence), we suggest that the issue could be addressed by meta-analysis of the present and future reports. The gene discussed is PPARG; the disease is metabolic dysfunction-associated steatohepatitis.