Furthermore, as shown in Additional file 1, resveratrol also suppressed the expression of iNOS and COX-2, the production of PGE2 and NO, the DNA-binding activities of NF-κB and AP-1 as well as the enzyme activity of MMP-13 in chondrocytes stimulated by another preparation of AGEs using glycoaldehyde-modified albumin that contains CML, pentosidine and other AGEs [19,20]. The gene discussed is JUN; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.