Our current data are not inconsistent with these earlier findings: early neutrophil influx (24 hours) did not differ between OPN KO and WT mice, whereas the fact that at 72 hours after infection lung MPO levels were lower in OPN KO mice likely was the consequence of the lower bacterial loads (providing a less potent chemotactic stimulus), possibly in combination with lower lung levels of the neutrophil chemoattractant KC. Here, SPP1 is linked to infection.