Genes which showed significantly reduced expression in the early TB granulomata, relative to normal lung tissues, included Th2 chemokines (CCL14, 24, 25), MAP kinases (MKNK2, MARK2, MAPK7, 11, 12, 15, 8IP3, 3K14, 3K6, BP1) calcium binding/signaling proteins (CABP2, CABP4, CACNA2D3, CAMK2A, CAMK2G, CAMKIIN, CALML3) and immune signaling repressors/negative regulators (BCOR, NFKBIL1, NFKBIL2, SOCS1, SOCS3) (Table S4). Here, SOCS1 is linked to tuberculosis.