Genes which showed significantly reduced expression in the early TB granulomata, relative to normal lung tissues, included Th2 chemokines (CCL14, 24, 25), MAP kinases (MKNK2, MARK2, MAPK7, 11, 12, 15, 8IP3, 3K14, 3K6, BP1) calcium binding/signaling proteins (CABP2, CABP4, CACNA2D3, CAMK2A, CAMK2G, CAMKIIN, CALML3) and immune signaling repressors/negative regulators (BCOR, NFKBIL1, NFKBIL2, SOCS1, SOCS3) (Table S4). The gene discussed is CALML3; the disease is tuberculosis.