Genes which showed significantly reduced expression in the early TB granulomata, relative to normal lung tissues, included Th2 chemokines (CCL14, 24, 25), MAP kinases (MKNK2, MARK2, MAPK7, 11, 12, 15, 8IP3, 3K14, 3K6, BP1) calcium binding/signaling proteins (CABP2, CABP4, CACNA2D3, CAMK2A, CAMK2G, CAMKIIN, CALML3) and immune signaling repressors/negative regulators (BCOR, NFKBIL1, NFKBIL2, SOCS1, SOCS3) (Table S4). This evidence concerns the gene MARK2 and tuberculosis.