Of the individual SNP analyses, only rs6548238 near TMEM18, rs10838738 in MTCH2, and rs7498665 near SH2B1 showed nominally significant interactions with physical activity level on BMI or obesity risk (Tables S3 and S4), but none survived adjustment for multiple comparisons. Here, TMEM18 is linked to obesity due to melanocortin 4 receptor deficiency.