A role for IL-17 in angiogenesis is supported by the recent findings that local overexpression of IL-17 in C57BL/6 mice induces arthritis with increased vascularity, and that IL-17 induces migration of endothelial cells in vitro, along with increased angiogenesis in Matrigel plugs [34]. The gene discussed is IL17A; the disease is arthritic joint disease.