In addition, the Apc-Cdkn1a network also suggests that certain interactions previously associated with other cancer models – such as the SRC-CCND1 functional association found in prostate cancer [39], or the phosphorylation of CDK4 by SRC in a cell line [40] – are relevant in this model of colon cancer. This evidence concerns the gene CDK4 and malignant colon neoplasm.