Increased levels of multiple cytokines including interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-alpha (TNF-α) have been detected in both the tear fluid of patients with dry eye symptoms [9-12] and also in animal models of the disease [7,8,13]. The gene discussed is CXCL8; the disease is Keratoconjunctivitis sicca.