Osteopontin immunohistochemistry score ranks and tumor grade and stage ranks were dependent (P<0.001) for all cancers combined (Figure 2A), as well as for 12 individual cancers for grade, 13 individual cancers for stage T, 8 individual cancers for stage N, and 9 individual cancers for stage M (Table 4). The gene discussed is SPP1; the disease is cancer.