IL6ST and cancer: In addition, gp130 was expressed both in the cytoplasm's cancer cell's and on membranes.Interleukin-6R and gp130 expression in colorectal cancer patients did not show a significant correlation with prognosis (data not shown), whereas the patients with positive IL-6 expression in the cytoplasm of cancer cells had significantly poorer prognoses than those with reduced IL-6 expression (Figure 3G; log-rank test, P=0.035).