EZH2 and in situ carcinoma: However, it is not known whether EZH2 is involved in actin regulation in CIS cells or whether the cytoplasmic location is a result of a defective translocation to the nucleus, but EZH2 is most probably not engaged in its ‘normal’ function as part of polycomb or swi/snf complexes as none of the genes encoding co-enzymes were observed overexpressed in CIS.