However, in 46 patients we were unable to make diagnosis may be because screening tests for other coagulation factor deficiencies that cause a bleeding disorder, such as hypoprothrombinemia, deficiencies of factor V, combined factor V and factor VIII, factor VII, factor X, and factor XIII, inherited as autosomal recessive traits, were not performed in this study. This evidence concerns the gene F10 and Congenital factor II deficiency.