However, in 46 patients we were unable to make diagnosis may be because screening tests for other coagulation factor deficiencies that cause a bleeding disorder, such as hypoprothrombinemia, deficiencies of factor V, combined factor V and factor VIII, factor VII, factor X, and factor XIII, inherited as autosomal recessive traits, were not performed in this study. The gene discussed is F10; the disease is complement factor I deficiency.