Mutual interactions between carcinoma cells and CAF were reported by Nakamura et al.: tumoral IL-1, basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) stimulate HGF expression in CAF, and in turn, stromal HGF leads to an invasive phenotype in carcinoma cells [94]. This evidence concerns the gene HGF and carcinoma.