In A375M2 melanoma cells, displaying a predominantly amoeboid phenotype with a minority of cells migrating in a mesenchymal fashion, Sanz-Moreno identified DOCK3 as a GEF specific for Rac1, NEDD9 as an adaptor protein of the p130Cas family binding DOCK3, and WAVE2 as a protein that promotes actin nucleation downstream of Rac [92]. The gene discussed is RAC1; the disease is melanoma.