Thus, in renal cell carcinoma [38], breast carcinoma [39], and gastric cancer [40], an inverse correlation has also been observed between Tiam1 expression and invasive potential, and Tiam1 expression in renal carcinoma cells inhibits migration by promoting E-cadherin-mediated adhesion [38]. The gene discussed is TIAM1; the disease is hereditary clear cell renal cell carcinoma.