To determine whether the contribution of Tiam1 to Golgi reorientation is restricted to the MDA-MB-231 cell line, we examined a third tumor cell line that expresses high levels of Tiam1, MDA-MB-435 S. Like all other cell lines we examined, Tiam1 is found in the perinuclear region of these cells, where it co-localizes with a marker for the Golgi (Figure 9a). This evidence concerns the gene TIAM1 and neoplasm.