MIP controls the intracellular levels of PI[3,5]P2,which in turn binds to a multitude of proteins [28-30],therefore working as a principal molecule in the coordination of intracellularnetworks [28,31].Intriguingly, we have recently obtained preliminary evidence that indicatesthat mature MIPKO develops cardiovascular diseases and osteoporosis, both inagreement of a broader and age-related role of MIP (Wacker, Andresen, Bonewald,Johnson & Brotto; unpublished observations). This evidence concerns the gene MIP and cardiovascular disorder.