Some new genes were incurred in a considerable amount of samples such as APOE and NOS3 in obesity (Fig. 5A), LDLR, APOE, and IL4 in T1DM (Fig. 5B), as well as POMC and CCL2 in T2DM (Fig. 5C). This evidence concerns the gene CCL2 and obesity due to melanocortin 4 receptor deficiency.