Some new genes were incurred in a considerable amount of samples such as APOE and NOS3 in obesity (Fig. 5A), LDLR, APOE, and IL4 in T1DM (Fig. 5B), as well as POMC and CCL2 in T2DM (Fig. 5C). The gene discussed is POMC; the disease is obesity due to melanocortin 4 receptor deficiency.