Some patients were positive for IgM anti HEV but negative for HEV-RNA (13.3%), reason behind that the viremia is short lived and disappeared prior to development of icterus or early in 1st week of development of icterus and the variation of nucleotide sequence in the primary regions among different HEV strains could be as high as 28%, which may account for the difficulty in PCR amplification [14]. Here, CD40LG is linked to Jaundice.